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3l6c
From Proteopedia
m (Protected "3l6c" [edit=sysop:move=sysop]) |
Revision as of 20:50, 4 April 2013
Contents |
X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor
Template:ABSTRACT PUBMED 20106978
Function
[SRR_RAT] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.[1] [2]
About this Structure
3l6c is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062
- ↑ Panatier A, Theodosis DT, Mothet JP, Touquet B, Pollegioni L, Poulain DA, Oliet SH. Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell. 2006 May 19;125(4):775-84. PMID:16713567 doi:10.1016/j.cell.2006.02.051
- ↑ Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062
Categories: Rattus norvegicus | Serine racemase | Barker, J. | Cesura, A. | Ebneth, A. | Felicetti, B. | Mack, V. | Mather, O. | Moraes, I. | Schonfeld, D. | Smith, M A. | Wood, M. | Isomerase | Plp | Pyridoxal phosphate
