3w3z
From Proteopedia
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| - | + | {{STRUCTURE_3w3z| PDB=3w3z | SCENE= }} | |
| + | ===Crystal structure of Kap121p bound to RanGTP=== | ||
| + | {{ABSTRACT_PUBMED_23541588}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/IMB3_YEAST IMB3_YEAST]] Involved in the nuclear import of ribosomal proteins. Binds to nucleoporins and the GTP-bound form of GSP1 (Ran). Plays a role in protein secretion. [[http://www.uniprot.org/uniprot/RAN_CANFA RAN_CANFA]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity). | ||
| - | + | ==About this Structure== | |
| - | + | [[3w3z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3Z OCA]. | |
| - | + | [[Category: Canis lupus familiaris]] | |
| + | [[Category: Saccharomyces cerevisiae s288c]] | ||
| + | [[Category: Kobayashi, J.]] | ||
| + | [[Category: Matsuura, Y.]] | ||
| + | [[Category: Heat repeat]] | ||
| + | [[Category: Nuclear import]] | ||
| + | [[Category: Protein transport-nuclear protein complex]] | ||
Revision as of 22:38, 10 April 2013
Crystal structure of Kap121p bound to RanGTP
Template:ABSTRACT PUBMED 23541588
Function
[IMB3_YEAST] Involved in the nuclear import of ribosomal proteins. Binds to nucleoporins and the GTP-bound form of GSP1 (Ran). Plays a role in protein secretion. [RAN_CANFA] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity).
About this Structure
3w3z is a 2 chain structure with sequence from Canis lupus familiaris and Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.
