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4jep
From Proteopedia
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| - | + | {{STRUCTURE_4jep| PDB=4jep | SCENE= }} | |
| + | ===Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)=== | ||
| + | {{ABSTRACT_PUBMED_23526564}} | ||
| - | The | + | ==Function== |
| + | [[http://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP). | ||
| - | + | ==About this Structure== | |
| - | + | [[4jep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEP OCA]. | |
| - | + | [[Category: Nucleoside-triphosphatase]] | |
| + | [[Category: Toxoplasma gondii]] | ||
| + | [[Category: Krug, U.]] | ||
| + | [[Category: Strater, N.]] | ||
| + | [[Category: Totzauer, R.]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Phosphatase]] | ||
Revision as of 22:50, 10 April 2013
Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)
Template:ABSTRACT PUBMED 23526564
Function
[NTP2_TOXGO] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
About this Structure
4jep is a 2 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.
