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3m02

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Template:STRUCTURE 3m02

Contents

The Crystal Structure of 5-epi-aristolochene synthase complexed with (2-cis,6-trans)-2-fluorofarnesyl diphosphate

Template:ABSTRACT PUBMED 20175559

Function

[5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.

About this Structure

3m02 is a 1 chain structure with sequence from Nicotiana tabacum. Full crystallographic information is available from OCA.

Reference

  • Noel JP, Dellas N, Faraldos JA, Zhao M, Hess BA, Smentek L, Coates RM, O'Maille PE. Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-Fluorofarnesyl Diphosphates. ACS Chem Biol. 2010 Mar 8. PMID:20175559 doi:10.1021/cb900295g

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OCA

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