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3mcf

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Template:STRUCTURE 3mcf

Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Function

[NUD10_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

About this Structure

3mcf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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