S100 protein

From Proteopedia

Revision as of 09:15, 17 April 2013

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S100 proteins are calcium-binding proteins (CBP) found in vertebrates and contain 2 helix-loop-helix calcium binding sites. S100 name is derived from their being 100% soluble in ammonium sulfate. There are at least 21 S100 proteins. Most S100 proteins undergo conformational change upon calcium binding.
S100-A1 is a regulator of myocardial contractility.
S100-A2 may have a tumor suppression function.
S100-A4 and S100-A11 may function in motility, invasion and tubulin polymerization.
S100-A6 may function in calcium-dependent insulin release.
S100-A7 is an antimicrobial peptide mainly against E. coli.
S100-A8 may function in the inhibition of casein kinase.
S100-A10 is implicated in the transport of neurotransmitters.
S100-A12 and S100-A13 may function in calcium-dependent signal transduction pathways.
S100-A15 is found in psoriatic skin and functions as antimicrobial peptide.
S100B levels increase in patients suffering from brain damage and are used as diagnostics for traumatic head injury.
S100G is vitamin-D dependent calcium-binding protein and is called calbindin D9k and calbindin D28k depending on its molecular weight. S100G mediates the transport of calcium across enterocytes.

3D Structures of S100 proteins

Updated on 17-April-2013

S100A

S100-A1

1k2h – rCBP-1 – rat - NMR
2k2f – rCBP-1 + Ca + ryanodine receptor peptide - NMR
2kbm – rCBP-1 + F-actin capping protein peptide - NMR
1zfs, 2lp2 – hCBP-1 + Ca – human - NMR
2l0p, 2lp3 – hCBP-1 + Ca - NMR
2lhl, 2lls – hCBP-1 (mutant) - NMR
2llt, 2llu – hCBP-1 - NMR
2jpt – bCBP-1 (mutant) – bovine - NMR

S100-A2

2rgi – hCBP-2
4duq – hCBP-2 (mutant) + Ca

S100-A3

3psr, 3nsi, 3nso – hCBP-3
3nsk, 3nsl – hCBP-3 (mutant)

S100-A4 (Metastasin, Placental calcium-binding protein, Calvasculin)

1m31 – hCBP-4 - NMR
2q91 – hCBP-4
3c1v, 3cga, 3ko0, 4hsz – hCBP-4 + Ca
3m0w – hCBP-4 + Ca + PCP
3zwh – hCBP-4 (mutant) + Ca + myosin-9 peptide
4eto – hCBP-4 + Ca + myosin-9 peptide
2lnk – hCBP-4 + myosin-2a peptide - NMR

S100-A5

2kax – hCBP-5 - NMR
4dir – hCBP-5 + Ca
2kay – hCBP-5 + Ca - NMR

S100-A6 (Calcyclin)

1cnp, 1a03, 2cnp, 1jwd – raCBP-6 – rabbit - NMR
2jtt – raCBP-6 + calcyclin-binding protein - NMR
1kso – hCBP-6
1k96, 1k9k – hCBP-6 + Ca

S100-A7 (Psoriasin)

1psr – hCBP-7 + Ho
2psr, 2wos – hCBP-7 + Zn + Ca
2wnd, 4aqj – hCBP-7 (mutant) + Zn + Ca
3psr, 2wor – hCBP-7 + Ca

S100-A8 (Calgranulin; Migration inhibitory factor-related protein)

1mr8 – hCBP-8 + Ca
1irj – hCBP-9 + Ca
1xk4 – hCBP-8 (mutant) + Ca + hCBP-9 (mutant)
4ggf – hCBP-8 + hCBP-9 + Ca + Mn

S100-A10 ( Calpaxin; P11)

1a4p – hCBP-10
1bt6 – hCBP-10 + annexin II
4drw, 4hrg – hCBP-10/annexin II + AHNAK peptide
4ftg – hCBP-10 + annexin II + AHNAK peptide
4hre, 4hrh – hCBP-10 + annexin II + helicase-like transcription factor

S100-A11 (Calgizzarin)

1qls – CBP-11 + Ca + annexin I - pig
1nsh – raCBP-11 - NMR

S100-A12

2wcf – hCBP-12
2wce – hCBP-12 (mutant)
1e8a, 1gqm – hCBP-12 + Ca
1odb – hCBP-12 + Cu + Ca
2wc8, 2wcb – hCBP-12 + Zn

S100-A13

2cxj – CBP-13 – mouse - NMR
1yur, 1yus – hCBP-13 - NMR
1yut, 1yuu – hCBP-13 + Ca - NMR
2h2k, 2egd – hCBP-13 + Ca
2k8m – hCBP-13 + peptide - NMR
2ki4 – hCBP-13 + heparin-binding growth factor - NMR
2ki6 – hCBP-13 + heparin-binding growth factor + synaptotagmin-1- NMR
2l5x – hCBP-13 + interleukin-1 α - NMR
2le9 – hCBP-13 + RAGEC2 - NMR
2kot – hCBP-13 + amlexanox - NMR

S100-A14

2m0r – hCBP-14 - NMR

S100-A15 (Koebnerisin)

4aqi – hCBP-15 + Ca + Zn

S100-A16

2l50 – hCBP-16 - NMR
2l51 – hCBP-16 + Ca - NMR
3nxa – hCBP-16

S100B

1sym, 1b4c – rCBP – rat - NMR
1qlk, 2k7o – rCBP + Ca - NMR
1xyd – rCBP + Zn + Ca - NMR
1dt7 – rCBP + Ca + p53 peptide - NMR
1mwn – rCBP + F-actin capping protein peptide - NMR
1mq1 – hCBP + F-actin capping protein peptide - NMR
3rm1 – bCBP + F-actin capping protein peptide + Ca
1psb – bCBP + NDR kinase peptide - NMR
3iqq – bCBP + TRTK12 peptide
1cfp – bCBP (mutant) - NMR
1mho, 3cr4, 3gk1, 3gk2, 3gk4, 3iqo, 3lk0, 3lk1, 3lle, 3rlz – bCBP + Ca
3cr2, 3cr5 – bCBP + Zn + Ca
4fqo – bCBP (mutant) + Ca + inhibitor
1uwo, 2pru – hCBP - NMR
2h61, 3hcm – hCBP + Ca
3czt, 3d0y, 3d10 – hCBP + Zn + Ca

S100G (Calbindin)

3icb – bCBP + Ca

Calbindin D9k

1clb – bCBP - NMR
1cdn, 1bod, 1d1o – bCBP (mutant) - NMR
4icb – bCBP + Ca
1ig5 – bCBP + Mg
1igv – bCBP + Mn
1boc, 2bca, 2bcb – bCBP - NMR
1ht9 – bCBP (mutant) + Ca
1qx2 – bCBP (mutant) + Zn + Ca
1b1g – bCBP (mutant) + Ca - NMR
1kqv, 1ksm, 1n65 – bCBP (mutant) + Lanthanide - NMR
1kcy – bCBP (mutant) - NMR
1cb1 – CBP – pig - NMR

S100P

1j55 – hCBP + Ca
1ozo – hCBP - NMR

S100Z

2y5i – CBP + Ca - zebrafish