This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3n5c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3n5c" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3n5c.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3n5c", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3n5c| PDB=3n5c | SCENE= }}
{{STRUCTURE_3n5c| PDB=3n5c | SCENE= }}
- 
===Crystal Structure of Arf6DELTA13 complexed with GDP===
===Crystal Structure of Arf6DELTA13 complexed with GDP===
 +
{{ABSTRACT_PUBMED_20709080}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/ARF6_HUMAN ARF6_HUMAN]] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.<ref>PMID:7589240</ref> <ref>PMID:14978216</ref> <ref>PMID:11266366</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20709080}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 20709080 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20709080}}
+
==About this Structure==
==About this Structure==
Line 22: Line 10:
==Reference==
==Reference==
-
<ref group="xtra">PMID:20709080</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020709080</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aizel, K.]]
[[Category: Aizel, K.]]
[[Category: Biou, V.]]
[[Category: Biou, V.]]
[[Category: Cherfils, J.]]
[[Category: Cherfils, J.]]
 +
[[Category: Adp-ribosylation factor 6]]
 +
[[Category: Arf]]
 +
[[Category: Endocytosis]]
 +
[[Category: Protein transport]]
 +
[[Category: Small g protein]]
 +
[[Category: Small gtp-binding protein]]
 +
[[Category: Traffic]]
 +
[[Category: Unfolded protein]]

Revision as of 20:48, 17 April 2013

Template:STRUCTURE 3n5c

Contents

Crystal Structure of Arf6DELTA13 complexed with GDP

Template:ABSTRACT PUBMED 20709080

Function

[ARF6_HUMAN] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.[1] [2] [3]

About this Structure

3n5c is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Biou V, Aizel K, Roblin P, Thureau A, Jacquet E, Hansson S, Guibert B, Guittet E, van Heijenoort C, Zeghouf M, Perez J, Cherfils J. SAXS and X-ray crystallography suggest an unfolding model for the GDP/GTP conformational switch of the small GTPase Arf6. J Mol Biol. 2010 Oct 1;402(4):696-707. Epub 2010 Aug 13. PMID:20709080 doi:10.1016/j.jmb.2010.08.002
  1. ↑ D'Souza-Schorey C, Stahl PD. Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp Cell Res. 1995 Nov;221(1):153-9. PMID:7589240 doi:http://dx.doi.org/10.1006/excr.1995.1362
  2. ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493
  3. ↑ Pasqualato S, Menetrey J, Franco M, Cherfils J. The structural GDP/GTP cycle of human Arf6. EMBO Rep. 2001 Mar;2(3):234-8. PMID:11266366 doi:10.1093/embo-reports/kve043

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3n5c"
Personal tools