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3mvb

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Template:STRUCTURE 3mvb

Contents

Crystal structure of a triple RFY mutant of human MTERF1 bound to the termination sequence

Template:ABSTRACT PUBMED 20550934

Function

[MTERF_HUMAN] Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity.[1]

About this Structure

3mvb is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Yakubovskaya E, Mejia E, Byrnes J, Hambardjieva E, Garcia-Diaz M. Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. Cell. 2010 Jun 11;141(6):982-93. PMID:20550934 doi:10.1016/j.cell.2010.05.018
  1. ↑ Yakubovskaya E, Mejia E, Byrnes J, Hambardjieva E, Garcia-Diaz M. Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. Cell. 2010 Jun 11;141(6):982-93. PMID:20550934 doi:10.1016/j.cell.2010.05.018

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OCA

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