3mtl
From Proteopedia
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{{STRUCTURE_3mtl| PDB=3mtl | SCENE= }} | {{STRUCTURE_3mtl| PDB=3mtl | SCENE= }} | ||
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===Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804=== | ===Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN]] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3mtl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTL OCA]. | |
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Cyclin-dependent kinase]] | [[Category: Cyclin-dependent kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Structural genomics consortium]] | [[Category: Structural genomics consortium]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 11:16:14 2010'' | ||
Revision as of 21:04, 17 April 2013
Contents |
Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
Function
[CDK16_HUMAN] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).[1] [2] [3]
About this Structure
3mtl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase. Cell Signal. 2012 Nov;24(11):2085-94. doi: 10.1016/j.cellsig.2012.06.018. Epub, 2012 Jul 11. PMID:22796189 doi:10.1016/j.cellsig.2012.06.018
- ↑ Chen XY, Gu XT, Saiyin H, Wan B, Zhang YJ, Li J, Wang YL, Gao R, Wang YF, Dong WP, Najjar SM, Zhang CY, Ding HF, Liu JO, Yu L. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. J Biol Chem. 2012 Aug 31;287(36):30368-75. doi: 10.1074/jbc.M112.375618. Epub, 2012 Jul 13. PMID:22798068 doi:10.1074/jbc.M112.375618
- ↑ Mikolcevic P, Sigl R, Rauch V, Hess MW, Pfaller K, Barisic M, Pelliniemi LJ, Boesl M, Geley S. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol Cell Biol. 2012 Feb;32(4):868-79. doi: 10.1128/MCB.06261-11. Epub 2011 Dec, 19. PMID:22184064 doi:10.1128/MCB.06261-11
Categories: Cyclin-dependent kinase | Homo sapiens | Amos, A. | Arrowsmith, C H. | Ayinampudi, V. | Berridge, G. | Bountra, C. | Bullock, A. | Burgess-Brown, N. | Das, S. | Delft, F von. | Edwards, A. | Fedorov, O. | Filippakopoulos, P. | Keates, T. | Knapp, S. | Krojer, T. | Muniz, J. | Phillips, C. | Pike, A C.W. | Rellos, P. | Roos, A. | SGC, Structural Genomics Consortium. | Savitsky, P. | Sharpe, T D. | Thangaratnarajah, C. | Ugochukwu, E. | Vollmar, M. | Weigelt, J. | Yue, W. | Zhang, Y. | Indirubin | Kinase | Pctaire1 | Sgc | Structural genomic | Structural genomics consortium | Transferase
