Serine/threonine protein kinase

From Proteopedia

Revision as of 12:06, 22 April 2013

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Serine/threonine protein kinase Chk1 (Chk1) phosphorylates cdc25A, cdc25B and cdc25C. Upon phosphorylation, cdc25 binds adaptor protein and the cell is prevented from entering mitosis. Chk2 phosphorylates cdc25C at Ser-216. Chk6 called also Aurora A is critical for the formation of mitotic spindles during cellular mitosis. Chk6 is phosphorylated at residues Thr287 and Thr288.

3D structures of serine/threonine protein kinase

Updated on 22-April-2013

Chk1

1nvq, 1nvr – hChk1 kinase domain+ peptide + saurosporine – human

1nvs, 1zys - hChk1 kinase domain + peptide + inhibitor

2cgu, 2cgv, 2cgw, 2cgx, 2c3j, 2c3k, 2c3l, 2br1, 2brb, 2brg, 2brh, 2brm, 2brn, 2bro, 2ayp, 2gdo, 2ghg, 2hog, 2ywp, 2hxl, 2hxq, 2hy0, 2r0u, 2e9n, 2e9o, 2e9p, 2e9u, 2e9v, 2qhm, 2qhn, 3f9n, 2wmq, 2wmr, 2wms, 2wmt, 2wmu, 2wmv, 2wmx, 3jvr, 3jvs, 2xey, 2xf0, 2xez, 2x8d, 2x8e, 2x8i, 3ot3, 3ot8, 3pa3, 3pa4, 3pa5, 3nlb - hChk1 kinase domain + inhibitor

Chk2

1gxc – hChk2 phosphothreonine-binding domain + phosphopeptide

2cn5 – hChk2 kinase domain + ADP

2cn8 – hChk2 kinase domain + inhibitor

2w0j, 2w7x, 2wtc, 2wtd, 2xbj, 2xm8, 2xm9, 2yiq, 2yir, 2yit - hChk2 kinase domain + inhibitor

3i6u, 3i6w – hChk2 residues 84-502 (mutant)

Chk6

1muo, 1mq4 – hChk6 kinase domain
1ol6 – hChk6 kinase domain (mutant) + ATP
2wqe – hChk6 kinase domain (mutant) + ADP
2c6d – hChk6 kinase domain (mutant) + ADPNP
2dwb – hChk6 kinase domain + AMPPNP
3daj, 3d14, 3dj5, 3dj6, 3dj7, 3d15, 3d2i, 3d2k – Chk6 kinase domain (mutant) + inhibitor - mouse
2j4z, 2j50, 2np8, 3efw, 2x81, 2x6d, 2x6e, 3myg, 3vap, 4b0g – hChk6 kinase domain + inhibitor
2bmc, 2c6e, 3coh, 3h0y, 3h0z, 3h10, 3fdn, 2wtw, 3lau, 3nrm, 2xne, 2xng, 2xru, 3k5u, 3m11, 3p9j, 3r21, 3r22, 3qbn, 3unz, 3uo4, 3uo5, 3uo6, 3uod, 3uoh, 3uoj, 3uok, 3uol, 3up2, 3up7, 4dhf, 4dea, 4deb, 4ded, 4dee – hChk6 kinase domain (mutant) + inhibitor

Chk6 with phosphorylated Thr 287, Thr288

1ol5, 1ol7 – hChk6 kinase domain + PThr + ADP
2w1c, 2w1d, 2w1e, 2w1f, 2w1g – hChk6 kinase domain + PThr + inhibitor
2wtv – hChk6 kinase domain (mutant) + PThr + inhibitor
3e5a, 3ha6 – hChk6 kinase domain + PThr + inhibitor + targeting protein for XKLP2

Rac-β hChk

1gzk, 1gzn, 1gzo – Rac-β hChk kinase domain
1p6s - Rac-β hChk pleckstrin homology domain - NMR
1o6k - Rac-β hChk kinase domain + GSK3 peptide + AMPPNP
1o6l - Rac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP

Various Chk

1c1y – hChk proto oncogene kinase domain + Ras-related protein Rap
2xiy, 2xiz, 2xj0 - hChk proto oncogene Pim-1 kinase domain
1u5q, 1u5r – rChk Tao2 kinase domain – rat
2cos – Chk Lats2 – mouse – NMR
2xik – hChk 25
3hgk – Chk Pto + effector protein AVRPTOB – Currant tomato
3ori, 3ork, 3orl, 3orm, 3oro, 3orp, 3ort - MtChk kinase domain (mutant) – Mycobacterium tuberculosis
3ouv - MtChk extracellular domain