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3o2t
From Proteopedia
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{{STRUCTURE_3o2t| PDB=3o2t | SCENE= }} | {{STRUCTURE_3o2t| PDB=3o2t | SCENE= }} | ||
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===Crystal structure of the N-terminal domain of human Symplekin=== | ===Crystal structure of the N-terminal domain of human Symplekin=== | ||
| + | {{ABSTRACT_PUBMED_20861839}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/SYMPK_HUMAN SYMPK_HUMAN]] Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.<ref>PMID:16230528</ref> <ref>PMID:20861839</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3o2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2T OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020861839</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Tong, L.]] | [[Category: Tong, L.]] | ||
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[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Scaffold]] | [[Category: Scaffold]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:06:57 2010'' | ||
Revision as of 11:40, 24 April 2013
Contents |
Crystal structure of the N-terminal domain of human Symplekin
Template:ABSTRACT PUBMED 20861839
Function
[SYMPK_HUMAN] Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.[1] [2]
About this Structure
3o2t is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010 Sep 22. PMID:20861839 doi:10.1038/nature09391
- ↑ Kolev NG, Steitz JA. Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. Genes Dev. 2005 Nov 1;19(21):2583-92. Epub 2005 Oct 17. PMID:16230528 doi:10.1101/gad.1371105
- ↑ Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010 Sep 22. PMID:20861839 doi:10.1038/nature09391
