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3nm9
From Proteopedia
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{{STRUCTURE_3nm9| PDB=3nm9 | SCENE= }} | {{STRUCTURE_3nm9| PDB=3nm9 | SCENE= }} | ||
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===HMGD(M13A)-DNA complex=== | ===HMGD(M13A)-DNA complex=== | ||
| + | {{ABSTRACT_PUBMED_20800069}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/HMGD_DROME HMGD_DROME]] Binds preferentially single-stranded DNA and unwinds double stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.<ref>PMID:1373803</ref> <ref>PMID:8168480</ref> <ref>PMID:7720717</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3nm9]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM9 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020800069</ref><references group="xtra"/><references/> |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Churchill, M E.A.]] | [[Category: Churchill, M E.A.]] | ||
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[[Category: Hmg domain]] | [[Category: Hmg domain]] | ||
[[Category: Non-sequence-specific]] | [[Category: Non-sequence-specific]] | ||
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Revision as of 11:46, 24 April 2013
Contents |
HMGD(M13A)-DNA complex
Template:ABSTRACT PUBMED 20800069
Function
[HMGD_DROME] Binds preferentially single-stranded DNA and unwinds double stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.[1] [2] [3]
About this Structure
3nm9 is a 16 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
- Churchill ME, Klass J, Zoetewey DL. Structural Analysis of HMGD-DNA Complexes Reveals Influence of Intercalation on Sequence Selectivity and DNA Bending. J Mol Biol. 2010 Aug 25. PMID:20800069 doi:10.1016/j.jmb.2010.08.031
- ↑ Wagner CR, Hamana K, Elgin SC. A high-mobility-group protein and its cDNAs from Drosophila melanogaster. Mol Cell Biol. 1992 May;12(5):1915-23. PMID:1373803
- ↑ Ner SS, Travers AA. HMG-D, the Drosophila melanogaster homologue of HMG 1 protein, is associated with early embryonic chromatin in the absence of histone H1. EMBO J. 1994 Apr 15;13(8):1817-22. PMID:8168480
- ↑ Churchill ME, Jones DN, Glaser T, Hefner H, Searles MA, Travers AA. HMG-D is an architecture-specific protein that preferentially binds to DNA containing the dinucleotide TG. EMBO J. 1995 Mar 15;14(6):1264-75. PMID:7720717
