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3o8g

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[[Image:3o8g.png|left|200px]]
 
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{{STRUCTURE_3o8g| PDB=3o8g | SCENE= }}
{{STRUCTURE_3o8g| PDB=3o8g | SCENE= }}
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===EthR from Mycobacterium tuberculosis in complex with compound BDM14801===
===EthR from Mycobacterium tuberculosis in complex with compound BDM14801===
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{{ABSTRACT_PUBMED_20704273}}
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==Function==
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[[http://www.uniprot.org/uniprot/P96222_MYCTU P96222_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 20704273 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20704273}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020704273</ref><references group="xtra"/>
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<ref group="xtra">PMID:020704273</ref><references group="xtra"/><references/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Baulard, A.]]
[[Category: Baulard, A.]]
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[[Category: Villeret, V.]]
[[Category: Villeret, V.]]
[[Category: Willand, N.]]
[[Category: Willand, N.]]
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[[Category: Dna]]
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[[Category: Dna binding protein]]
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[[Category: Inhibitor]]
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[[Category: Tetr-family]]
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[[Category: Transcription repressor-inhibitor complex]]
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[[Category: Transcritptional regulatory repressor]]

Revision as of 11:53, 24 April 2013

Template:STRUCTURE 3o8g

Contents

EthR from Mycobacterium tuberculosis in complex with compound BDM14801

Template:ABSTRACT PUBMED 20704273

Function

[P96222_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).[1] [2]

About this Structure

3o8g is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Willand N, Desroses M, Toto P, Dirie B, Lens Z, Villeret V, Rucktooa P, Locht C, Baulard A, Deprez B. Exploring Drug Target Flexibility Using in Situ Click Chemistry: Application to a Mycobacterial Transcriptional Regulator. ACS Chem Biol. 2010 Aug 26. PMID:20704273 doi:10.1021/cb100177g
  1. ↑ Baulard AR, Betts JC, Engohang-Ndong J, Quan S, McAdam RA, Brennan PJ, Locht C, Besra GS. Activation of the pro-drug ethionamide is regulated in mycobacteria. J Biol Chem. 2000 Sep 8;275(36):28326-31. PMID:10869356 doi:10.1074/jbc.M003744200
  2. ↑ DeBarber AE, Mdluli K, Bosman M, Bekker LG, Barry CE 3rd. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9677-82. PMID:10944230

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