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3ny6
From Proteopedia
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{{STRUCTURE_3ny6| PDB=3ny6 | SCENE= }} | {{STRUCTURE_3ny6| PDB=3ny6 | SCENE= }} | ||
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===Catalytic fragment of cholix toxin from vibrio cholerae in complex with inhibitor V30=== | ===Catalytic fragment of cholix toxin from vibrio cholerae in complex with inhibitor V30=== | ||
| + | {{ABSTRACT_PUBMED_21135177}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021135177</ref><references group="xtra"/><references/> |
[[Category: Vibrio cholerae]] | [[Category: Vibrio cholerae]] | ||
[[Category: Jorgensen, R.]] | [[Category: Jorgensen, R.]] | ||
[[Category: Merrill, A R.]] | [[Category: Merrill, A R.]] | ||
| + | [[Category: Adp-ribosyl transferase]] | ||
| + | [[Category: Alpha-beta complex]] | ||
| + | [[Category: Nad+ binding]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 12:06, 24 April 2013
Contents |
Catalytic fragment of cholix toxin from vibrio cholerae in complex with inhibitor V30
Template:ABSTRACT PUBMED 21135177
Function
[Q5EK40_VIBCH] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.[1] [2]
About this Structure
3ny6 is a 1 chain structure with sequence from Vibrio cholerae. Full crystallographic information is available from OCA.
Reference
- Turgeon Z, Jorgensen R, Visschedyk D, Edwards PR, Legree S, McGregor C, Fieldhouse RJ, Mangroo D, Schapira M, Merrill AR. Newly Discovered and Characterized Antivirulence Compounds inhibit Bacterial Mono-ADP-ribosyltransferase Toxins. Antimicrob Agents Chemother. 2010 Dec 6. PMID:21135177 doi:10.1128/AAC.01164-10
- ↑ Jorgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Rod Merrill A. Cholix toxin, a novel ADP-ribosylating factor from vibrio cholerae. J Biol Chem. 2008 Feb 25;. PMID:18276581 doi:M710008200
- ↑ Turgeon Z, White D, Jorgensen R, Visschedyk D, Fieldhouse RJ, Mangroo D, Merrill AR. Yeast as a tool for characterizing mono-ADP-ribosyltransferase toxins. FEMS Microbiol Lett. 2009 Nov;300(1):97-106. Epub 2009 Aug 31. PMID:19793133 doi:10.1111/j.1574-6968.2009.01777.x
