Sandbox Reserved 694

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== Receptor Binding ==
== Receptor Binding ==
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The two cellular receptors that the PA heptamer binds to for translocation are the <scene name='Sandbox_Reserved_694/Cmg2_receptor/1'>Capillary Morphogenesis Protein 2 (CMG2)</scene> and <scene name='Sandbox_Reserved_694/Atrtem8_receptor/1'>Anthrax Toxin Receptor/Tumor Endothelial Marker 8 (ATR/TEM8)</scene> plasma membrane receptors. <scene name='Sandbox_Reserved_694/Receptor_heptamer_binding/1'>Heptamer-receptor binding</scene> induces a conformational change to occur in the receptor that induces receptor-mediated endocytosis to occur.
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The two cellular receptors that the PA heptamer binds to for translocation are the <scene name='Sandbox_Reserved_694/Cmg2_receptor/1'>Capillary Morphogenesis Protein 2 (CMG2)</scene> and <scene name='Sandbox_Reserved_694/Atrtem8_receptor/1'>Anthrax Toxin Receptor/Tumor Endothelial Marker 8 (ATR/TEM8)</scene> plasma membrane receptors. <scene name='Sandbox_Reserved_694/Receptor_heptamer_binding/1'>Heptamer-receptor binding</scene> induces a conformational change to occur in the receptor that induces receptor-mediated endocytosis to occur. This process forms a vesicle that engulfs the PA heptamer and translocates it across the plasma membrane and into the cytosol where it can then release its anthrax toxic factors to interfere with cellular signaling pathways.

Revision as of 22:19, 27 April 2013

This Sandbox is Reserved from 30/01/2013, through 30/12/2013 for use in the course "Biochemistry II" taught by Hannah Tims at the Messiah College. This reservation includes Sandbox Reserved 686 through Sandbox Reserved 700.
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THE ANTHRAX PROTECTIVE ANTIGEN

Anthrax protective antigen complex (blue) with stabilizing Ca2+ (green) (PDB ID: 1ACC)

Drag the structure with the mouse to rotate

by Matt Wier

Tetrameric Structure

The is a tetrameric protein that functions to bind to host receptors on the plasma membrane to translocate the anthrax toxin factors into the host cell. The monomer form contains that each serve unique functions. The contains a Furin cleavage site, the binding site for the toxin factors, and two Calcium ions (green) for stabilizaion. The contains a flexible loop to aid in plasma membrane insertion. The interacts with other PA's in the heptamer form. The is the most important domain because it can undergo a conformational change to allow heptamerization to occur. Monomer PA's must oligomerize to form a before it can bind to host receptors and translocate the toxin into the cell.

Receptor Binding

The two cellular receptors that the PA heptamer binds to for translocation are the and plasma membrane receptors. induces a conformational change to occur in the receptor that induces receptor-mediated endocytosis to occur. This process forms a vesicle that engulfs the PA heptamer and translocates it across the plasma membrane and into the cytosol where it can then release its anthrax toxic factors to interfere with cellular signaling pathways.

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