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4ijo

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4ijo| PDB=4ijo | SCENE= }}
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===Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases===
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{{ABSTRACT_PUBMED_23583775}}
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The entry 4ijo is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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Authors: Udi, Y., Fragai, M., Grossman, M., Mitternacht, S., Arad-Yellin, R., Calderone, V., Melikian, M., Toccafondi, M., Berezovsky, I.N., Luchinat, C., Sagi, I.
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==About this Structure==
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[[4ijo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJO OCA].
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Description: Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases
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==Reference==
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<ref group="xtra">PMID:017096442</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Macrophage elastase]]
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[[Category: Arad-Yellin, R.]]
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[[Category: Berezovsky, I N.]]
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[[Category: Calderone, V.]]
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[[Category: Fragai, M.]]
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[[Category: Grossman, M.]]
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[[Category: Luchinat, C.]]
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[[Category: Melikian, M.]]
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[[Category: Mitternacht, S.]]
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[[Category: Sagi, I.]]
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[[Category: Toccafondi, M.]]
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[[Category: Udi, Y.]]
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[[Category: Amphiphol]]
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[[Category: Degradation of the extracellular matrix protein]]
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[[Category: Extracellular]]
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[[Category: Hydrolase]]
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[[Category: Matrix metalloproteinase]]
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[[Category: Regulatory site]]

Revision as of 07:37, 2 May 2013

Template:STRUCTURE 4ijo

Contents

Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases

Template:ABSTRACT PUBMED 23583775

Function

[MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

About this Structure

4ijo is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ. Snapshots of the reaction mechanism of matrix metalloproteinases. Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:17096442 doi:10.1002/anie.200603100

Proteopedia Page Contributors and Editors (what is this?)

OCA

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