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3opt

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Template:STRUCTURE 3opt

Contents

Crystal structure of the Rph1 catalytic core with a-ketoglutarate

Template:ABSTRACT PUBMED 21067515

Function

[RPH1_YEAST] Transcriptional repressor of photolyase PHR1. Recognizes and binds the sequence AG(4) in the upstream repressing sequence of PHR1. Derepresses PHR1 transcription when phosphorylated.[1] [2]

About this Structure

3opt is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Chang Y, Wu J, Tong XJ, Zhou JQ, Ding J. Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism. Biochem J. 2010 Nov 10. PMID:21067515 doi:10.1042/BJ20101418
  1. ↑ Jang YK, Wang L, Sancar GB. RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol. 1999 Nov;19(11):7630-8. PMID:10523651
  2. ↑ Kim EM, Jang YK, Park SD. Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Nucleic Acids Res. 2002 Feb 1;30(3):643-8. PMID:11809875

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OCA

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