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3ote
From Proteopedia
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===Crystal structure of human tRNAHis guanylyltransferase (Thg1)- Native I=== | ===Crystal structure of human tRNAHis guanylyltransferase (Thg1)- Native I=== | ||
| + | {{ABSTRACT_PUBMED_21059936}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/THG1_HUMAN THG1_HUMAN]] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.<ref>PMID:21059936</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3ote]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTE OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021059936</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Doublie, S.]] | [[Category: Doublie, S.]] | ||
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[[Category: Polymerase-like palm domain]] | [[Category: Polymerase-like palm domain]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:21:55 2010'' | ||
Revision as of 08:23, 2 May 2013
Contents |
Crystal structure of human tRNAHis guanylyltransferase (Thg1)- Native I
Template:ABSTRACT PUBMED 21059936
Function
[THG1_HUMAN] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.[1]
About this Structure
3ote is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublie S. tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 8. PMID:21059936 doi:10.1073/pnas.1010436107
- ↑ Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublie S. tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 8. PMID:21059936 doi:10.1073/pnas.1010436107
