Taylor sandboxk ricin rRNA modification site
From Proteopedia
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== Site of ricin modification of rRNA == | == Site of ricin modification of rRNA == | ||
| - | <StructureSection load=' | + | <StructureSection load='3u5d' size='400' side='right' caption='ribosomal RNA from Yeast(PDB entry [[3u5d]])' scene=''> |
| - | Ricin removes an adenine from a specific portion of the 28S rRNA. This | + | Ricin removes an adenine from a specific portion of the 28S rRNA called the <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Sarcin-ricin_loop/1'>sacrin-ricin loop</scene>, or SRL. This <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Depurination/1'>depurination</scene> leads to reduced binding of elongation factors to the ribosome and reduced synthesis of proteins. It also triggers apoptosis via activation of the JNK pathway (citation). |
| - | binding of elongation factors to the ribosome and reduced | + | |
While the structure of an eukaryotic ribosome is known, it is not at the level of detail to be able to precisely map this location. What is known about the location of the depurination is: | While the structure of an eukaryotic ribosome is known, it is not at the level of detail to be able to precisely map this location. What is known about the location of the depurination is: | ||
Revision as of 05:15, 4 May 2013
Site of ricin modification of rRNA
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