Taylor sandboxk ricin rRNA modification site
From Proteopedia
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== Site of ricin modification of rRNA == | == Site of ricin modification of rRNA == | ||
<StructureSection load='3u5d' size='400' side='right' caption='ribosomal RNA from Yeast(PDB entry [[3u5d]])' scene=''> | <StructureSection load='3u5d' size='400' side='right' caption='ribosomal RNA from Yeast(PDB entry [[3u5d]])' scene=''> | ||
| - | Ricin removes an adenine from a specific portion of the 28S rRNA called the <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Sarcin-ricin_loop/1'>sacrin-ricin loop</scene>, or SRL. This <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Depurination/1'>depurination</scene> leads to reduced binding of elongation factors to the ribosome and reduced synthesis of proteins. It also triggers apoptosis via activation of the JNK pathway | + | Ricin removes an adenine from a specific portion of the 28S rRNA called the <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Sarcin-ricin_loop/1'>sacrin-ricin loop</scene>, or SRL. This <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Depurination/1'>depurination</scene> leads to reduced binding of elongation factors to the ribosome and reduced synthesis of proteins. It also triggers apoptosis via activation of the JNK pathway <ref name="Iordanov">PMID: 9154836</ref>. |
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Current revision
Site of ricin modification of rRNA
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