3qik
From Proteopedia
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{{STRUCTURE_3qik| PDB=3qik | SCENE= }} | {{STRUCTURE_3qik| PDB=3qik | SCENE= }} | ||
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===Crystal structure of the first PDZ domain of PREX1=== | ===Crystal structure of the first PDZ domain of PREX1=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Tong, Y.]] | [[Category: Tong, Y.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
| + | [[Category: Hydrolase regulator]] | ||
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Structural genomics consortium]] | ||
Revision as of 08:32, 8 May 2013
Crystal structure of the first PDZ domain of PREX1
Function
[PREX1_HUMAN] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
About this Structure
3qik is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
