This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1up0
From Proteopedia
| Line 25: | Line 25: | ||
[[Category: glycoside hydrolase]] | [[Category: glycoside hydrolase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:07:36 2007'' |
Revision as of 14:02, 30 October 2007
|
STRUCTURE OF THE ENDOGLUCANASE CEL6 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CELLOBIOSE AT 1.75 ANGSTROM
Overview
The genomes of various Mycobacterium tuberculosis strains encode proteins, that do not appear to play a role in the growth or survival of the, bacterium in its mammalian host, including some implicated in plant cell, wall breakdown. Here we show that M. tuberculosis H37Rv does indeed, possess a functional cellulase. The x-ray crystal structure of this, enzyme, in ligand complex forms, from 1.9 to 1.1A resolution, reveals a, highly conserved substrate-binding cleft, which affords similar, and, unusual, distortion of the substrate at the catalytic center. The, endoglucanase activity, together with the existence of a putative, membrane-associated crystalline polysaccharide-binding protein, may, reflect the ancestral soil origin of the Mycobacterium or hint at a, previously unconsidered ... [(full description)]
About this Structure
1UP0 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with SO4, ACT and 1PG as [ligands]. Structure known Active Site: 1. Full crystallographic information is available from [OCA].
Reference
Mycobacterium tuberculosis strains possess functional cellulases., Varrot A, Leydier S, Pell G, Macdonald JM, Stick RV, Henrissat B, Gilbert HJ, Davies GJ, J Biol Chem. 2005 May 27;280(21):20181-4. Epub 2005 Apr 11. PMID:15824123
Page seeded by OCA on Tue Oct 30 16:07:36 2007
Categories: Mycobacterium tuberculosis | Single protein | Davies, G.J. | Gilbert, H.J. | Leydier, S. | Pell, G. | Varrot, A. | 1PG | ACT | SO4 | Family 6 | Glycoside hydrolase
