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3rom
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_3rom| PDB=3rom | SCENE= }} | |
| + | ===Crystal structure of human CD38 in complex with compound CZ-48=== | ||
| + | {{ABSTRACT_PUBMED_22142305}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | ||
| - | + | ==About this Structure== | |
| + | [[3rom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROM OCA]. | ||
| - | + | ==See Also== | |
| + | *[[Cluster of Differentiation 38|Cluster of Differentiation 38]] | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022142305</ref><references group="xtra"/><references/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Hao, Q.]] | ||
| + | [[Category: Lee, H C.]] | ||
| + | [[Category: Zhang, H.]] | ||
| + | [[Category: Adp-ribosyl cyclase]] | ||
| + | [[Category: Calcium signaling]] | ||
| + | [[Category: Cd38]] | ||
| + | [[Category: Covalent intermediate]] | ||
| + | [[Category: Cyclic adp-ribose]] | ||
| + | [[Category: Cz-48]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Inhibitory compound]] | ||
| + | [[Category: X-crystallography]] | ||
Revision as of 08:06, 16 May 2013
Contents |
Crystal structure of human CD38 in complex with compound CZ-48
Template:ABSTRACT PUBMED 22142305
Function
[CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
About this Structure
3rom is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Kwong AK, Chen Z, Zhang H, Leung FP, Lam CM, Ting KY, Zhang L, Hao Q, Zhang LH, Lee HC. Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38. Biochemistry. 2011 Dec 14. PMID:22142305 doi:10.1021/bi201509f
