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3w4k

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'''Unreleased structure'''
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{{STRUCTURE_3w4k| PDB=3w4k | SCENE= }}
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===Crystal Structure of human DAAO in complex with coumpound 13===
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{{ABSTRACT_PUBMED_23566269}}
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The entry 3w4k is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
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Authors: Hondo, T., Warizaya, M., Niimi, T., Namatame, I., Yamaguchi, T., Nakanishi, K., Hamajima, T., Harada, K., Sakashita, H., Matsumoto, Y., Orita, M., Watanabe, T., Takeuchi, M.
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==About this Structure==
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[[3w4k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W4K OCA].
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Description: Crystal Structure of human DAAO in complex with coumpound 13
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==Reference==
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<ref group="xtra">PMID:023566269</ref><references group="xtra"/><references/>
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[[Category: D-amino-acid oxidase]]
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[[Category: Homo sapiens]]
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[[Category: Hamajima, T.]]
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[[Category: Harada, K.]]
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[[Category: Hondo, T.]]
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[[Category: Matsumoto, Y.]]
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[[Category: Nakanishi, K.]]
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[[Category: Namatame, I.]]
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[[Category: Niimi, T.]]
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[[Category: Orita, M.]]
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[[Category: Sakashita, H.]]
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[[Category: Takeuchi, M.]]
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[[Category: Warizaya, M.]]
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[[Category: Watanabe, T.]]
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[[Category: Yamaguchi, T.]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 15:17, 19 June 2013

Template:STRUCTURE 3w4k

Contents

Crystal Structure of human DAAO in complex with coumpound 13

Template:ABSTRACT PUBMED 23566269

Function

[OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.[1]

About this Structure

3w4k is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hondo T, Warizaya M, Niimi T, Namatame I, Yamaguchi T, Nakanishi K, Hamajima T, Harada K, Sakashita H, Matsumoto Y, Orita M, Takeuchi M. 4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors. J Med Chem. 2013 May 9;56(9):3582-92. doi: 10.1021/jm400095b. Epub 2013 Apr 25. PMID:23566269 doi:10.1021/jm400095b
  1. ↑ Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007 Apr 6;355(2):385-91. Epub 2007 Feb 8. PMID:17303072 doi:10.1016/j.bbrc.2007.01.181

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