This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4jnh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4jnh" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4jnh| PDB=4jnh | SCENE= }}
 +
===A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid===
 +
{{ABSTRACT_PUBMED_23675305}}
-
The entry 4jnh is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/GAG_FOAMV GAG_FOAMV]] Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome.<ref>PMID:16160174</ref> <ref>PMID:12857789</ref>
-
Authors: Taylor, I.A., Goldstone, D.C., Flower, T.G., Ball, N.J.
+
==About this Structure==
 +
[[4jnh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_spumaretrovirus Human spumaretrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNH OCA].
-
Description: A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid
+
==Reference==
 +
<ref group="xtra">PMID:023675305</ref><references group="xtra"/><references/>
 +
[[Category: Human spumaretrovirus]]
 +
[[Category: Ball, N J.]]
 +
[[Category: Flower, T G.]]
 +
[[Category: Goldstone, D C.]]
 +
[[Category: Taylor, I A.]]
 +
[[Category: Coiled-coil]]
 +
[[Category: Env]]
 +
[[Category: Gag]]
 +
[[Category: Viral protein]]

Revision as of 15:42, 19 June 2013

Template:STRUCTURE 4jnh

Contents

A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid

Template:ABSTRACT PUBMED 23675305

Function

[GAG_FOAMV] Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome.[1] [2]

About this Structure

4jnh is a 2 chain structure with sequence from Human spumaretrovirus. Full crystallographic information is available from OCA.

Reference

  • Goldstone DC, Flower TG, Ball NJ, Sanz-Ramos M, Yap MW, Ogrodowicz RW, Stanke N, Reh J, Lindemann D, Stoye JP, Taylor IA. A Unique Spumavirus Gag N-terminal Domain with Functional Properties of Orthoretroviral Matrix and Capsid. PLoS Pathog. 2013 May;9(5):e1003376. doi: 10.1371/journal.ppat.1003376. Epub 2013, May 9. PMID:23675305 doi:10.1371/journal.ppat.1003376
  1. ↑ Cartellieri M, Herchenroder O, Rudolph W, Heinkelein M, Lindemann D, Zentgraf H, Rethwilm A. N-terminal Gag domain required for foamy virus particle assembly and export. J Virol. 2005 Oct;79(19):12464-76. PMID:16160174 doi:79/19/12464
  2. ↑ Petit C, Giron ML, Tobaly-Tapiero J, Bittoun P, Real E, Jacob Y, Tordo N, De The H, Saib A. Targeting of incoming retroviral Gag to the centrosome involves a direct interaction with the dynein light chain 8. J Cell Sci. 2003 Aug 15;116(Pt 16):3433-42. PMID:12857789 doi:http://dx.doi.org/10.1242/jcs.00613

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jnh"
Personal tools