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4gfl

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4gfl| PDB=4gfl | SCENE= }}
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===NO mechanism, slma===
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{{ABSTRACT_PUBMED_23754405}}
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The entry 4gfl is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SLMA_KLEP3 SLMA_KLEP3]] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).
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Authors: Schumacher, M.A.
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==About this Structure==
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[[4gfl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_342 Klebsiella pneumoniae 342]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFL OCA].
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Description: NO mechanism, slma
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==Reference==
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<ref group="xtra">PMID:023754405</ref><references group="xtra"/><references/>
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[[Category: Klebsiella pneumoniae 342]]
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[[Category: Schumacher, M A.]]
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[[Category: Cell division]]
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[[Category: Cytokinesis]]
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[[Category: Dna binding protein]]
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[[Category: Ftsz]]
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[[Category: No]]
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[[Category: Nucleoid occlusion]]
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[[Category: Slma]]

Revision as of 16:01, 19 June 2013

Template:STRUCTURE 4gfl

Contents

NO mechanism, slma

Template:ABSTRACT PUBMED 23754405

Function

[SLMA_KLEP3] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).

About this Structure

4gfl is a 2 chain structure with sequence from Klebsiella pneumoniae 342. Full crystallographic information is available from OCA.

Reference

  • Tonthat NK, Milam SL, Chinnam N, Whitfill T, Margolin W, Schumacher MA. SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid. Proc Natl Acad Sci U S A. 2013 Jun 10. PMID:23754405 doi:10.1073/pnas.1221036110

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OCA

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