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3zmh

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_3zmh| PDB=3zmh | SCENE= }}
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===Structure of E.coli rhomboid protease GlpG in complex with monobactam L62===
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{{ABSTRACT_PUBMED_23665170}}
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The entry 3zmh is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/GLPG_ECOLI GLPG_ECOLI]] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.<ref>PMID:17099694</ref> <ref>PMID:16216077</ref>
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Authors: Vinothkumar, K.R., Pierrat, O.A., Large, J.M., Freeman, M.
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==About this Structure==
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[[3zmh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZMH OCA].
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Description: Structure of E.coli rhomboid protease GlpG in complex with monobactam L62
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==Reference==
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<ref group="xtra">PMID:023665170</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli]]
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[[Category: Rhomboid protease]]
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[[Category: Freeman, M.]]
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[[Category: Large, J M.]]
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[[Category: Pierrat, O A.]]
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[[Category: Vinothkumar, K R.]]
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[[Category: Acyl enzyme]]
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[[Category: Anitbiotic]]
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[[Category: Beta lactam]]
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[[Category: Hydrolase]]
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[[Category: Intra-membrane protease]]

Revision as of 16:28, 19 June 2013

Template:STRUCTURE 3zmh

Contents

Structure of E.coli rhomboid protease GlpG in complex with monobactam L62

Template:ABSTRACT PUBMED 23665170

Function

[GLPG_ECOLI] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.[1] [2]

About this Structure

3zmh is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Vinothkumar KR, Pierrat OA, Large JM, Freeman M. Structure of Rhomboid Protease in Complex with beta-Lactam Inhibitors Defines the S2' Cavity. Structure. 2013 May 7. pii: S0969-2126(13)00117-2. doi:, 10.1016/j.str.2013.03.013. PMID:23665170 doi:10.1016/j.str.2013.03.013
  1. ↑ Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol. 2006 Dec;13(12):1084-91. Epub 2006 Nov 10. PMID:17099694 doi:10.1038/nsmb1179
  2. ↑ Maegawa S, Ito K, Akiyama Y. Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane. Biochemistry. 2005 Oct 18;44(41):13543-52. PMID:16216077 doi:10.1021/bi051363k

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