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4jvb

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4jvb| PDB=4jvb | SCENE= }}
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===Crystal structure of PDE6D in complex with the inhibitor rac-2===
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{{ABSTRACT_PUBMED_23698361}}
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The entry 4jvb is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
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Authors: Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
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==About this Structure==
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[[4jvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVB OCA].
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Description: Crystal structure of PDE6D in complex with the inhibitor rac-2
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==Reference==
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<ref group="xtra">PMID:023698361</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Bastiaens, P.]]
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[[Category: Chandra, A.]]
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[[Category: Gunther, Z.]]
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[[Category: Hahn, S.]]
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[[Category: Hoffmann, M.]]
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[[Category: Ismail, S.]]
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[[Category: Papke, B.]]
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[[Category: Triola, G.]]
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[[Category: Vartak, N.]]
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[[Category: Waldmann, H.]]
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[[Category: Wittinghofer, A.]]
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[[Category: Gdi-like solubilizing factor]]
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[[Category: Immunoglobulin-like beta-sandwich]]
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[[Category: Prenyl binding]]
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[[Category: Protein binding-inhibitor complex]]

Revision as of 17:56, 19 June 2013

Template:STRUCTURE 4jvb

Contents

Crystal structure of PDE6D in complex with the inhibitor rac-2

Template:ABSTRACT PUBMED 23698361

Function

[PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).

About this Structure

4jvb is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H. Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling. Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22. PMID:23698361 doi:10.1038/nature12205

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OCA

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