2hm1
From Proteopedia
(New page: 200px<br /> <applet load="2hm1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hm1, resolution 2.200Å" /> '''Crystal Structure ...) |
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| - | [[Image:2hm1.gif|left|200px]]<br /> | + | [[Image:2hm1.gif|left|200px]]<br /><applet load="2hm1" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2hm1" size=" | + | |
caption="2hm1, resolution 2.200Å" /> | caption="2hm1, resolution 2.200Å" /> | ||
'''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)'''<br /> | '''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We describe an optimized series of acyclic hydroxyethylamine transition | + | We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown. |
==About this Structure== | ==About this Structure== | ||
| - | 2HM1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with LIQ as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http:// | + | 2HM1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=LIQ:'>LIQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HM1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Benson, T | + | [[Category: Benson, T E.]] |
| - | [[Category: Emmons, T | + | [[Category: Emmons, T L.]] |
| - | [[Category: Paddock, D | + | [[Category: Paddock, D J.]] |
| - | [[Category: Prince, D | + | [[Category: Prince, D B.]] |
| - | [[Category: Tomasselli, A | + | [[Category: Tomasselli, A G.]] |
[[Category: LIQ]] | [[Category: LIQ]] | ||
[[Category: protein-inhibitor complex]] | [[Category: protein-inhibitor complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:43:19 2008'' |
Revision as of 15:43, 21 February 2008
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Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)
Overview
We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown.
About this Structure
2HM1 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Memapsin 2, with EC number 3.4.23.46 Full crystallographic information is available from OCA.
Reference
Design of potent inhibitors of human beta-secretase. Part 2., Freskos JN, Fobian YM, Benson TE, Moon JB, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G, Bioorg Med Chem Lett. 2007 Jan 1;17(1):78-81. Epub 2006 Oct 4. PMID:17049233
Page seeded by OCA on Thu Feb 21 17:43:19 2008
