This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2hnx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="2hnx" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hnx, resolution 1.50&Aring;" /> '''Crystal Structure o...)
Line 1: Line 1:
-
[[Image:2hnx.gif|left|200px]]<br />
+
[[Image:2hnx.gif|left|200px]]<br /><applet load="2hnx" size="350" color="white" frame="true" align="right" spinBox="true"
-
<applet load="2hnx" size="450" color="white" frame="true" align="right" spinBox="true"
+
caption="2hnx, resolution 1.50&Aring;" />
caption="2hnx, resolution 1.50&Aring;" />
'''Crystal Structure of aP2'''<br />
'''Crystal Structure of aP2'''<br />
==Overview==
==Overview==
-
Human adipocyte lipid-binding protein (aP2) belongs to a family of, intracellular lipid-binding proteins involved in the transport and storage, of lipids. Here, the crystal structure of human aP2 with a bound palmitate, is described at 1.5 A resolution. Unlike the known crystal structure of, murine aP2 in complex with palmitate, this structure shows that the fatty, acid is in a folded conformation and that the loop containing Phe57 acts, as a lid to regulate ligand binding by excluding solvent exposure to the, central binding cavity.
+
Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity.
==About this Structure==
==About this Structure==
-
2HNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PO4, PLM and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HNX OCA].
+
2HNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=PLM:'>PLM</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNX OCA].
==Reference==
==Reference==
-
Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17077479 17077479]
+
Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17077479 17077479]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 17: Line 16:
[[Category: Karam, G.]]
[[Category: Karam, G.]]
[[Category: Marr, E.]]
[[Category: Marr, E.]]
-
[[Category: Phillips, T.Brown.]]
+
[[Category: Phillips, T Brown.]]
[[Category: Qiu, X.]]
[[Category: Qiu, X.]]
[[Category: Tardie, M.]]
[[Category: Tardie, M.]]
Line 25: Line 24:
[[Category: fatty acid binding protein]]
[[Category: fatty acid binding protein]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:34:31 2007''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:43:45 2008''

Revision as of 15:43, 21 February 2008

Image:2hnx.gif

2hnx, resolution 1.50Å

Drag the structure with the mouse to rotate

Crystal Structure of aP2

Overview

Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity.

About this Structure

2HNX is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.

Reference

Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:17077479

Page seeded by OCA on Thu Feb 21 17:43:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hnx"
Personal tools