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2bc8

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[[Image:2bc8.png|left|200px]]
 
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{{STRUCTURE_2bc8| PDB=2bc8 | SCENE= }}
{{STRUCTURE_2bc8| PDB=2bc8 | SCENE= }}
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===[Sec2,3,8,12]-ImI===
===[Sec2,3,8,12]-ImI===
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{{ABSTRACT_PUBMED_16500898}}
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{{ABSTRACT_PUBMED_16500898}}
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==Function==
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[[http://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016500898</ref><references group="xtra"/>
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<ref group="xtra">PMID:016500898</ref><references group="xtra"/><references/>
[[Category: Armishaw, C J.]]
[[Category: Armishaw, C J.]]
[[Category: Conotoxin]]
[[Category: Conotoxin]]

Revision as of 07:43, 30 June 2013

Template:STRUCTURE 2bc8

Contents

[Sec2,3,8,12]-ImI

Template:ABSTRACT PUBMED 16500898

Function

[CA1_CONIM] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.[1]

About this Structure

2bc8 is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Armishaw CJ, Daly NL, Nevin ST, Adams DJ, Craik DJ, Alewood PF. Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists. J Biol Chem. 2006 May 19;281(20):14136-43. Epub 2006 Feb 24. PMID:16500898 doi:M512419200
  1. ↑ McIntosh JM, Yoshikami D, Mahe E, Nielsen DB, Rivier JE, Gray WR, Olivera BM. A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI. J Biol Chem. 1994 Jun 17;269(24):16733-9. PMID:8206995

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OCA

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