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4idj

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4idj| PDB=4idj | SCENE= }}
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===S.Aureus a-hemolysin monomer in complex with Fab===
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{{ABSTRACT_PUBMED_23416200}}
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The entry 4idj is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU]] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
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Authors: Strop, P.
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==About this Structure==
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[[4idj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDJ OCA].
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Description: S.Aureus a-hemolysin monomer in complex with Fab
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==Reference==
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<ref group="xtra">PMID:023416200</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Staphylococcus aureus]]
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[[Category: Strop, P.]]
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[[Category: Cytolytic protein]]
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[[Category: Fab]]
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[[Category: Hemolysin complex with fab]]
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[[Category: Immune system]]
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[[Category: Secreted]]

Revision as of 09:51, 30 June 2013

Template:STRUCTURE 4idj

Contents

S.Aureus a-hemolysin monomer in complex with Fab

Template:ABSTRACT PUBMED 23416200

Function

[HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.

About this Structure

4idj is a 3 chain structure with sequence from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

  • Foletti D, Strop P, Shaughnessy L, Hasa-Moreno A, Casas MG, Russell M, Bee C, Wu S, Pham A, Zeng Z, Pons J, Rajpal A, Shelton D. Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus alpha-hemolysin. J Mol Biol. 2013 May 27;425(10):1641-54. doi: 10.1016/j.jmb.2013.02.008. Epub, 2013 Feb 13. PMID:23416200 doi:10.1016/j.jmb.2013.02.008

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OCA

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