4jlt

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'''Unreleased structure'''
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{{STRUCTURE_4jlt| PDB=4jlt | SCENE= }}
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===Crystal structure of P450 2B4(H226Y) in complex with paroxetine===
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{{ABSTRACT_PUBMED_23633618}}
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The entry 4jlt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CP2B4_RABIT CP2B4_RABIT]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.
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Authors: Shah, M.B., Pascual, J., Stout, C.D., Halpert, J.R.
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==About this Structure==
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[[4jlt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLT OCA].
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Description: Crystal structure of P450 2B4(H226Y) in complex with paroxetine
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==Reference==
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<ref group="xtra">PMID:023633618</ref><references group="xtra"/><references/>
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[[Category: Oryctolagus cuniculus]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Halpert, J R.]]
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[[Category: Pascual, J.]]
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[[Category: Shah, M B.]]
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[[Category: Stout, C D.]]
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[[Category: Cyp 2b4]]
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[[Category: Cytochrome p450 2b4]]
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[[Category: Me protein]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: P450]]

Revision as of 10:16, 30 June 2013

Template:STRUCTURE 4jlt

Contents

Crystal structure of P450 2B4(H226Y) in complex with paroxetine

Template:ABSTRACT PUBMED 23633618

Function

[CP2B4_RABIT] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.

About this Structure

4jlt is a 1 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

  • Shah MB, Kufareva I, Pascual J, Zhang Q, Stout CD, Halpert JR. A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States. J Pharmacol Exp Ther. 2013 Jul;346(1):113-20. doi: 10.1124/jpet.113.204776. Epub , 2013 Apr 30. PMID:23633618 doi:10.1124/jpet.113.204776

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OCA

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