Integrin

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<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>
<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>
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'''Integrins''' (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α (or '''CD49a''') and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain.
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'''Integrins''' (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain.
==3D structures of integrin==
==3D structures of integrin==
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[[1n3y]] - hIG I domain (mutant)
[[1n3y]] - hIG I domain (mutant)
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===IG α-1===
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===IG α-1 (CD49a)===
[[1ck4]] - rIG I domain – rat<br />
[[1ck4]] - rIG I domain – rat<br />
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[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
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===IG α-2===
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===IG α-2 (CD49b)===
[[1dzi]] - hIG I domain + collagen peptide<br />
[[1dzi]] - hIG I domain + collagen peptide<br />
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[[2luv]] – hIG cytoplasmic domain – NMR<BR />
[[2luv]] – hIG cytoplasmic domain – NMR<BR />
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===IG α-1 β-1===
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===IG α-1 β-1 (CD49a-CD49b)===
[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
[[1pt6]] - hIG I domain + Mg<br />
[[1pt6]] - hIG I domain + Mg<br />
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===IG α-2 β===
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===IG α-2 (CD49b) β===
[[1aox]] - hIG I domain (mutant) + Mg<br />
[[1aox]] - hIG I domain (mutant) + Mg<br />
[[1s4w]] - hIG cytoplasmic domain]] - NMR<BR />
[[1s4w]] - hIG cytoplasmic domain]] - NMR<BR />
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===IG α-2b β-3===
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===IG α-2b β-3 (CD61)===
[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
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[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
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===IG α-4 β-7===
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===IG α-4 (CD49d) β-7===
[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
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===IG α-5 β-1===
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===IG α-5 (CD49e) β-1 (CD29)===
[[3vi3]] - hIG headpiece + antibody + Mg<br />
[[3vi3]] - hIG headpiece + antibody + Mg<br />
[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
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===IG α-5 β-3===
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===IG α-5 (CD49e) β-3 (CD61)===
[[3ije]] – hIG + Ca<br />
[[3ije]] – hIG + Ca<br />
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[[1l5g]] - hIG I domain + tripeptide + Mn<br />
[[1l5g]] - hIG I domain + tripeptide + Mn<br />
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===IG α-X β-2===
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===IG α-X β-2 (CD18)===
[[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br />
[[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br />
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===IG β-2===
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===IG β-2 (CD18)===
[[2p26]], [[2p28]] – hIG phe2 + phe3 domains
[[2p26]], [[2p28]] – hIG phe2 + phe3 domains
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===IG β-3===
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===IG β-3 (CD61)===
[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR />
[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR />
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[[2l91]] - hIG transmembrane domain (mutant) – NMR<BR />
[[2l91]] - hIG transmembrane domain (mutant) – NMR<BR />
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===IG β-4===
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===IG β-4 (CD104)===
[[2f7q]], [[3f7r]] - hIG fibronectin type III domain<br />
[[2f7q]], [[3f7r]] - hIG fibronectin type III domain<br />

Revision as of 09:08, 1 July 2013

Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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