This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2m9e

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{STRUCTURE_2m9e| PDB=2m9e | SCENE= }}
{{STRUCTURE_2m9e| PDB=2m9e | SCENE= }}
===NMR solution structure of Pin1 WW domain mutant 5-1===
===NMR solution structure of Pin1 WW domain mutant 5-1===
 +
{{ABSTRACT_PUBMED_23742246}}
==Function==
==Function==
Line 9: Line 10:
==Reference==
==Reference==
-
<references group="xtra"/><references/>
+
<ref group="xtra">PMID:023742246</ref><references group="xtra"/><references/>
[[Category: Chen, W.]]
[[Category: Chen, W.]]
[[Category: Dyson, H J.]]
[[Category: Dyson, H J.]]

Revision as of 09:04, 3 July 2013

Template:STRUCTURE 2m9e

Contents

NMR solution structure of Pin1 WW domain mutant 5-1

Template:ABSTRACT PUBMED 23742246

Function

[PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.[1] [2] [3]

About this Structure

2m9e is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Chen W, Enck S, Price JL, Powers DL, Powers ET, Wong CH, Dyson HJ, Kelly JW. The Structural and Energetic Basis of Carbohydrate-Aromatic Packing Interactions in Proteins. J Am Chem Soc. 2013 Jun 7. PMID:23742246 doi:10.1021/ja4040472
  1. ↑ Dougherty MK, Muller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK. Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell. 2005 Jan 21;17(2):215-24. PMID:15664191 doi:10.1016/j.molcel.2004.11.055
  2. ↑ Yu L, Mohamed AJ, Vargas L, Berglof A, Finn G, Lu KP, Smith CI. Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1. J Biol Chem. 2006 Jun 30;281(26):18201-7. Epub 2006 Apr 27. PMID:16644721 doi:10.1074/jbc.M603090200
  3. ↑ Lee TH, Chen CH, Suizu F, Huang P, Schiene-Fischer C, Daum S, Zhang YJ, Goate A, Chen RH, Zhou XZ, Lu KP. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Mol Cell. 2011 Apr 22;42(2):147-59. doi: 10.1016/j.molcel.2011.03.005. Epub 2011 , Apr 14. PMID:21497122 doi:10.1016/j.molcel.2011.03.005

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2m9e"
Personal tools