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2obo

From Proteopedia

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[[Image:2obo.png|left|200px]]
 
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{{STRUCTURE_2obo| PDB=2obo | SCENE= }}
{{STRUCTURE_2obo| PDB=2obo | SCENE= }}
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===Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776===
===Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776===
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{{ABSTRACT_PUBMED_17444623}}
{{ABSTRACT_PUBMED_17444623}}
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==Reference==
==Reference==
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<ref group="xtra">PMID:017444623</ref><ref group="xtra">PMID:008861917</ref><ref group="xtra">PMID:016087332</ref><ref group="xtra">PMID:016112859</ref><ref group="xtra">PMID:016112862</ref><ref group="xtra">PMID:016352601</ref><references group="xtra"/>
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<ref group="xtra">PMID:017444623</ref><references group="xtra"/><references/>
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Arasappan, A.]]
[[Category: Arasappan, A.]]

Revision as of 11:36, 3 July 2013

Template:STRUCTURE 2obo

Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776

Template:ABSTRACT PUBMED 17444623

About this Structure

2obo is a 4 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl] - 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J Med Chem. 2007 May 17;50(10):2310-8. Epub 2007 Apr 20. PMID:17444623 doi:10.1021/jm060173k

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OCA

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