2i6e

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(New page: 200px<br /><applet load="2i6e" size="350" color="white" frame="true" align="right" spinBox="true" caption="2i6e, resolution 2.50&Aring;" /> '''Crystal structure of...)
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==Overview==
==Overview==
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ABSTRACT: BACKGROUND: Pfam is a comprehensive collection of protein, domains and families, with a range of well-established information, including genome annotation. Pfam has two large series of functionally, uncharacterized families, known as Domains of Unknown Function (DUFs) and, Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of, two proteins from Deinococcus radiodurans and Streptomyces coelicolor, belonging to Pfam protein family DUF178 (ID: PF02621) have been determined, using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on, the structure, we have identified the putative function for this family of, protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably, similar to Pfam family DUF191 suggesting that the sequence-based, classification alone may not be sufficient to classify proteins into Pfam, families.
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BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7(1):62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17908300 17908300]
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X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17908300 17908300]
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Burley, S.K.]]
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[[Category: Burley, S K.]]
[[Category: Kumaran, D.]]
[[Category: Kumaran, D.]]
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[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Swaminathan, S.]]
[[Category: Swaminathan, S.]]
[[Category: Tyagi, R.]]
[[Category: Tyagi, R.]]
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[[Category: unknown function]]
[[Category: unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:48:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:49:35 2008''

Revision as of 15:49, 21 February 2008

Image:2i6e.gif

2i6e, resolution 2.50Å

Drag the structure with the mouse to rotate

Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178

Overview

BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.

About this Structure

2I6E is a Single protein structure of sequence from Deinococcus radiodurans with as ligand. Full crystallographic information is available from OCA.

Reference

X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:17908300

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