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4k7q

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'''Unreleased structure'''
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{{STRUCTURE_4k7q| PDB=4k7q | SCENE= }}
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===Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution===
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{{ABSTRACT_PUBMED_23673416}}
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The entry 4k7q is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
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Authors: Hung, L.W., Kim, H.B., Murakami, S., Gupta, G., Kim, C.Y., Terwilliger, T.C.
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==About this Structure==
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[[4k7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7Q OCA].
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Description: Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution
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==Reference==
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<ref group="xtra">PMID:023673416</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli k-12]]
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[[Category: Gupta, G.]]
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[[Category: Hung, L W.]]
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[[Category: Kim, C Y.]]
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[[Category: Kim, H B.]]
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[[Category: Murakami, S.]]
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[[Category: Terwilliger, T C.]]
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[[Category: Inner membrane resistance-nodulation-cell division efflux pump]]
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[[Category: Membrane protein-antibiotic complex]]

Revision as of 14:07, 3 July 2013

Template:STRUCTURE 4k7q

Contents

Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution

Template:ABSTRACT PUBMED 23673416

Function

[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]

About this Structure

4k7q is a 1 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Hung LW, Kim HB, Murakami S, Gupta G, Kim CY, Terwilliger TC. Crystal structure of AcrB complexed with linezolid at 3.5 A resolution. J Struct Funct Genomics. 2013 Jun;14(2):71-5. doi: 10.1007/s10969-013-9154-x., Epub 2013 May 15. PMID:23673416 doi:10.1007/s10969-013-9154-x
  1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
  2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
  3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007

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