2i9f
From Proteopedia
(New page: 200px<br /><applet load="2i9f" size="350" color="white" frame="true" align="right" spinBox="true" caption="2i9f, resolution 2.00Å" /> '''Structure of the equ...) |
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==Overview== | ==Overview== | ||
| - | Equine arteritis virus (EAV) is an enveloped positive-sense RNA virus | + | Equine arteritis virus (EAV) is an enveloped positive-sense RNA virus belonging to the Arteriviridae family, which also includes the porcine pathogen PRRSV and is genetically and structurally related to the coronaviruses. EAV is an important equine pathogen that has caused significant economic losses to the horse-breeding industry and has been difficult to control. The EAV virion consists of a genome-containing nucleocapsid core made of nucleocapsid (N) protein surrounded by a lipid envelope containing several membrane proteins. Here, the crystal structure of the capsid-forming domain of the EAV N protein is presented at 2.0 A resolution. The dimeric N-protein structure is similar to the previously determined structure of the N protein from PRRSV, with most differences localized to the terminal helices and flexible loops. The N protein is organized as dimers of dimers in the crystal, which may reflect the arrangement of the protein in the viral nucleocapsid. |
==About this Structure== | ==About this Structure== | ||
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[[Category: virus]] | [[Category: virus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:50:19 2008'' |
Revision as of 15:50, 21 February 2008
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Structure of the equine arterivirus nucleocapsid protein
Overview
Equine arteritis virus (EAV) is an enveloped positive-sense RNA virus belonging to the Arteriviridae family, which also includes the porcine pathogen PRRSV and is genetically and structurally related to the coronaviruses. EAV is an important equine pathogen that has caused significant economic losses to the horse-breeding industry and has been difficult to control. The EAV virion consists of a genome-containing nucleocapsid core made of nucleocapsid (N) protein surrounded by a lipid envelope containing several membrane proteins. Here, the crystal structure of the capsid-forming domain of the EAV N protein is presented at 2.0 A resolution. The dimeric N-protein structure is similar to the previously determined structure of the N protein from PRRSV, with most differences localized to the terminal helices and flexible loops. The N protein is organized as dimers of dimers in the crystal, which may reflect the arrangement of the protein in the viral nucleocapsid.
About this Structure
2I9F is a Single protein structure of sequence from Equine arteritis virus with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the equine arteritis virus nucleocapsid protein reveals a dimer-dimer arrangement., Deshpande A, Wang S, Walsh MA, Dokland T, Acta Crystallogr D Biol Crystallogr. 2007 May;63(Pt 5):581-6. Epub 2007, Apr 21. PMID:17452783
Page seeded by OCA on Thu Feb 21 17:50:19 2008
Categories: Equine arteritis virus | Single protein | Deshpande, A. | Dokland, T. | Walsh, M. | Wang, S. | CL | DTT | GOL | NA | Assembly | Capsid | Crystallography | Structure | Virus
