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2m13
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[2m13]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M13 OCA]. | + | [[2m13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M13 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023500490</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023500490</ref><references group="xtra"/><references/> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Elazzouzi, F.]] | [[Category: Elazzouzi, F.]] | ||
[[Category: Hilburn, B C.]] | [[Category: Hilburn, B C.]] | ||
Revision as of 14:22, 3 July 2013
Contents |
The ZZ domain of cytoplasmic polyadenylation element binding protein 1 (CPEB1)
Template:ABSTRACT PUBMED 23500490
Function
[CPEB1_HUMAN] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.[1] [2]
About this Structure
2m13 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Merkel DJ, Wells SB, Hilburn BC, Elazzouzi F, Perez-Alvarado GC, Lee BM. The C-Terminal Region of Cytoplasmic Polyadenylation Element Binding Protein Is a ZZ Domain with Potential for Protein-Protein Interactions. J Mol Biol. 2013 Mar 13. pii: S0022-2836(13)00156-3. doi:, 10.1016/j.jmb.2013.03.009. PMID:23500490 doi:10.1016/j.jmb.2013.03.009
- ↑ Sasayama T, Marumoto T, Kunitoku N, Zhang D, Tamaki N, Kohmura E, Saya H, Hirota T. Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1. Genes Cells. 2005 Jul;10(7):627-38. PMID:15966895 doi:10.1111/j.1365-2443.2005.00870.x
- ↑ Wilczynska A, Aigueperse C, Kress M, Dautry F, Weil D. The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules. J Cell Sci. 2005 Mar 1;118(Pt 5):981-92. PMID:15731006 doi:118/5/981
