Selectin

Selectin or CD62 are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: E-selectin found in endothelial cells; L-selectin found in leukocytes; P-selectin found in platelets. Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the bleed vessel walls, slowing their motion and enabling them to enter the site of infection.

3D structures of selectin

Updated on 04-July-2013

P-selectin

1fsb – hCD62P EGF domain – human - NMR

1g1q – hCD62P EGF domain
1g1r – hCD62P EGF domain + tetrasaccharide
1g1s – hCD62P EGF domain +P-selectin glycoprotein ligand peptide
4gxb – hCD62P intracellular domain + sorting nexin-17

L-selectin

3cfw – hCD62L EGF domain

2lgf – hCD62L calmodulin-binding domain + calmodulin

E-selectin

1esl – hCD62E EGF domain

1g1t – hCD62E EGF domain + tetrasaccharide