This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4h23
From Proteopedia
| Line 1: | Line 1: | ||
{{STRUCTURE_4h23| PDB=4h23 | SCENE= }} | {{STRUCTURE_4h23| PDB=4h23 | SCENE= }} | ||
===Cytochrome P450BM3-CIS cyclopropanation catalyst=== | ===Cytochrome P450BM3-CIS cyclopropanation catalyst=== | ||
| + | {{ABSTRACT_PUBMED_23792734}} | ||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4h23]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H23 OCA]. | [[4h23]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H23 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023792734</ref><references group="xtra"/><references/> | ||
[[Category: Bacillus megaterium]] | [[Category: Bacillus megaterium]] | ||
[[Category: Unspecific monooxygenase]] | [[Category: Unspecific monooxygenase]] | ||
Revision as of 14:30, 10 July 2013
Contents |
Cytochrome P450BM3-CIS cyclopropanation catalyst
Template:ABSTRACT PUBMED 23792734
Function
[CPXB_BACME] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.
About this Structure
4h23 is a 2 chain structure with sequence from Bacillus megaterium. Full crystallographic information is available from OCA.
Reference
- Coelho PS, Wang ZJ, Ener ME, Baril SA, Kannan A, Arnold FH, Brustad EM. A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nat Chem Biol. 2013 Jun 23. doi: 10.1038/nchembio.1278. PMID:23792734 doi:10.1038/nchembio.1278
