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4au5

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'''Unreleased structure'''
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{{STRUCTURE_4au5| PDB=4au5 | SCENE= }}
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===Structure of the NhaA dimer, crystallised at low pH===
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The entry 4au5 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NHAA_ECOLI NHAA_ECOLI]] Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5.<ref>PMID:1645730</ref>
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Authors: Drew, D., Lee, C., Iwata, S., Cameron, A.D.
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==About this Structure==
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[[4au5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AU5 OCA].
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Description: Structure of the NhaA dimer, crystallised at low pH
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Escherichia coli]]
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[[Category: Cameron, A D.]]
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[[Category: Drew, D.]]
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[[Category: Iwata, S.]]
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[[Category: Lee, C.]]
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[[Category: Membrane protein]]
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[[Category: Transporter]]

Revision as of 15:49, 10 July 2013

Template:STRUCTURE 4au5

Contents

Structure of the NhaA dimer, crystallised at low pH

Function

[NHAA_ECOLI] Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5.[1]

About this Structure

4au5 is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  1. ↑ Taglicht D, Padan E, Schuldiner S. Overproduction and purification of a functional Na+/H+ antiporter coded by nhaA (ant) from Escherichia coli. J Biol Chem. 1991 Jun 15;266(17):11289-94. PMID:1645730

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