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4bqm

From Proteopedia

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m (Protected "4bqm" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bqm| PDB=4bqm | SCENE= }}
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===Crystal structure of human liver-type glutaminase, catalytic domain===
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The entry 4bqm is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/GLSL_HUMAN GLSL_HUMAN]] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.<ref>PMID:20378837</ref>
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Authors: Ferreira, I.M., Vollmar, M., Krojer, T., Strain-Damerell, C., Froese, S., Coutandin, D., Williams, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Dias, S.M.G., Ambrosio, A.L.B., Yue, W.W.
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==About this Structure==
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[[4bqm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQM OCA].
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Description: Crystal structure of human liver-type glutaminase, catalytic domain
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Glutaminase]]
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[[Category: Homo sapiens]]
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[[Category: Ambrosio, A L.B.]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Coutandin, D.]]
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[[Category: Delft, F von.]]
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[[Category: Dias, S M.G.]]
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[[Category: Edwards, A.]]
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[[Category: Ferreira, I M.]]
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[[Category: Froese, S.]]
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[[Category: Krojer, T.]]
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[[Category: Strain-Damerell, C.]]
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[[Category: Vollmar, M.]]
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[[Category: Williams, E.]]
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[[Category: Yue, W W.]]
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[[Category: Hydrolase]]

Revision as of 15:51, 10 July 2013

Template:STRUCTURE 4bqm

Contents

Crystal structure of human liver-type glutaminase, catalytic domain

Function

[GLSL_HUMAN] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.[1]

About this Structure

4bqm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7455-60. doi:, 10.1073/pnas.1001006107. Epub 2010 Apr 8. PMID:20378837 doi:10.1073/pnas.1001006107

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OCA

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