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4ixh
From Proteopedia
| Line 13: | Line 13: | ||
[[Category: Cryptosporidium parvum]] | [[Category: Cryptosporidium parvum]] | ||
[[Category: IMP dehydrogenase]] | [[Category: IMP dehydrogenase]] | ||
| - | [[Category: | + | [[Category: Anderson, W F.]] |
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]] | [[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]] | ||
[[Category: Gu, M.]] | [[Category: Gu, M.]] | ||
Revision as of 04:30, 18 July 2013
Contents |
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum
Template:ABSTRACT PUBMED 23668331
Function
[IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[1]
About this Structure
4ixh is a 4 chain structure with sequence from Cryptosporidium parvum. Full crystallographic information is available from OCA.
Reference
- Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase. J Med Chem. 2013 May 23;56(10):4028-43. doi: 10.1021/jm400241j. Epub 2013 May 13. PMID:23668331 doi:10.1021/jm400241j
- ↑ Umejiego NN, Li C, Riera T, Hedstrom L, Striepen B. Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. J Biol Chem. 2004 Sep 24;279(39):40320-7. Epub 2004 Jul 21. PMID:15269207 doi:10.1074/jbc.M407121200
Categories: Cryptosporidium parvum | IMP dehydrogenase | Anderson, W F. | CSGID, Center for Structural Genomics of Infectious Diseases. | Gu, M. | Hedstrom, L. | Joachimiak, A. | Kavitha, M. | Kim, Y. | Makowska-Grzyska, M. | Alpha-beta fold | Center for structural genomics of infectious disease | Csgid | National institute of allergy and infectious disease | Niaid | Oxidoreductase | Structural genomic | Tim barrel
