Dioxygenase

Protocatechuate 3,4-dioxygenase (PCD) catalyzes the oxygenation of dihydroxybenzoate (DHB) to 3-carboxy-muconate. PCD participates in the aromatic compound benzoate degredation and uses Fe as cofactor. PCD consists of 8 subunits each containing an Fe and a substrate binding site. Each of these subunits is composed of α and β chains. Hydroxyphenyl acetate is an inhibitor of PCD.

3D structures of rotocatechuate 3,4-dioxygenase

Updated on 24-July-2013

2pcd – PpPCD α,β + Fe+3 – Pseudomonas putida

3pcd, 1ykk, 1ykm, 1yko, 3lkt, 3mfl, 3mi1, 3mv4, 3t63 – PpPCD α,β (mutant) + Fe+3
1eo2, 1eo9, 1eoa, 2bum, 2but – AcPCD α,β + Fe+3 - Acinetobacter
2bux – AcPCD α,β (mutant) + Fe+3

PCD complex with aromatic compound

3pcf, 3pch, 3pci – PpPCD α,β + Fe+3 + HB derivative

3pca, 3pcb, 3pcc – PpPCD α,β + Fe+3 + HB
1ykl, 1ykn, 1ykp, 3lmx, 3mv6 – PpPCD α,β (mutant) + Fe+3 + DHB
3pcj, 3pck, 3pcl, 3pcm – PpPCD α,β + Fe+3 + hydroxynicotinic acid derivative
3pcn, 3pce, 3pcg – PpPCD α,β + Fe+3 + hydroxyphenyl acetate derivative
1eob – AcPCD α,β + Fe+3 + DHB
2buv, 2bv0 – AcPCD α,β (mutant) + Fe+3 + DHB
2bur – AcPCD α,β + Fe+3 + HB
2buw – AcPCD α,β (mutant) + Fe+3 + HB
1eoc, 2buq – AcPCD α,β + Fe+3 + catechol derivative
2buu, 2buy, 2buz – AcPCD α,β (mutant) + Fe+3 + catechol derivative
3lxv, 3mi5, 3t67 – PpPCD α,β (mutant) + Fe+3 + catechol derivative