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4i27
From Proteopedia
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{{STRUCTURE_4i27| PDB=4i27 | SCENE= }} | {{STRUCTURE_4i27| PDB=4i27 | SCENE= }} | ||
===Ternary complex of mouse TdT with ssDNA and incoming nucleotide=== | ===Ternary complex of mouse TdT with ssDNA and incoming nucleotide=== | ||
| + | {{ABSTRACT_PUBMED_23856622}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4i27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I27 OCA]. | [[4i27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I27 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023856622</ref><references group="xtra"/><references/> | ||
[[Category: DNA nucleotidylexotransferase]] | [[Category: DNA nucleotidylexotransferase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
Revision as of 03:35, 1 August 2013
Contents |
Ternary complex of mouse TdT with ssDNA and incoming nucleotide
Template:ABSTRACT PUBMED 23856622
Function
[TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
About this Structure
4i27 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Gouge J, Rosario S, Romain F, Beguin P, Delarue M. Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J Mol Biol. 2013 Jul 13. pii: S0022-2836(13)00441-5. doi:, 10.1016/j.jmb.2013.07.009. PMID:23856622 doi:10.1016/j.jmb.2013.07.009
