2j1v
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The Streptococcus pneumoniae fucose utilization operon includes a gene | + | The Streptococcus pneumoniae fucose utilization operon includes a gene encoding a virulence factor that belongs to family 98 in the glycoside hydrolase classification. This protein contains a C-terminal triplet of fucose binding modules that have significant amino acid sequence identity with the Anguilla anguilla fucolectin. Functional studies of these fucose binding modules reveal binding to fucosylated oligosaccharides and suggest the importance of multivalent binding. The high resolution crystal structures of ligand bound forms of one fucose binding module uncovers the molecular basis of fucose, ABH blood group antigen, and Lewisy antigen binding. These studies are extended by fluorescence microscopy to show specific binding to mouse lung tissue. These modules define a new family of carbohydrate binding modules now classified as family 47. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
| - | [[Category: Boraston, A | + | [[Category: Boraston, A B.]] |
| - | [[Category: Burke, R | + | [[Category: Burke, R D.]] |
[[Category: Wang, D.]] | [[Category: Wang, D.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: carbohydrate binding protein]] | [[Category: carbohydrate binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:58:25 2008'' |
Revision as of 15:58, 21 February 2008
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STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE IN COMPLEX WITH THE BLOOD GROUP H-TRISACCHARIDE
Overview
The Streptococcus pneumoniae fucose utilization operon includes a gene encoding a virulence factor that belongs to family 98 in the glycoside hydrolase classification. This protein contains a C-terminal triplet of fucose binding modules that have significant amino acid sequence identity with the Anguilla anguilla fucolectin. Functional studies of these fucose binding modules reveal binding to fucosylated oligosaccharides and suggest the importance of multivalent binding. The high resolution crystal structures of ligand bound forms of one fucose binding module uncovers the molecular basis of fucose, ABH blood group antigen, and Lewisy antigen binding. These studies are extended by fluorescence microscopy to show specific binding to mouse lung tissue. These modules define a new family of carbohydrate binding modules now classified as family 47.
About this Structure
2J1V is a Single protein structure of sequence from Streptococcus pneumoniae with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Blood group antigen recognition by a Streptococcus pneumoniae virulence factor., Boraston AB, Wang D, Burke RD, J Biol Chem. 2006 Nov 17;281(46):35263-71. Epub 2006 Sep 20. PMID:16987809
Page seeded by OCA on Thu Feb 21 17:58:25 2008
