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2w8o

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{{STRUCTURE_2w8o| PDB=2w8o | SCENE= }}
{{STRUCTURE_2w8o| PDB=2w8o | SCENE= }}
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===THE CRYSTAL STRUCTURE OF THE REDUCED FORM OF HUMAN SSADH===
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===The crystal structure of the reduced form of human SSADH===
{{ABSTRACT_PUBMED_19300440}}
{{ABSTRACT_PUBMED_19300440}}
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==Function==
==Function==
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[[http://www.uniprot.org/uniprot/SSDH_HUMAN SSDH_HUMAN]] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).<ref>PMID:19300440</ref>
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[[http://www.uniprot.org/uniprot/SSDH_HUMAN SSDH_HUMAN]] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).<ref>PMID:19300440</ref>
==About this Structure==
==About this Structure==
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<ref group="xtra">PMID:019300440</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:019300440</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Succinate-semialdehyde dehydrogenase]]
 
[[Category: Kim, K J.]]
[[Category: Kim, K J.]]
[[Category: Kim, Y G.]]
[[Category: Kim, Y G.]]

Revision as of 19:03, 7 August 2013

Template:STRUCTURE 2w8o

Contents

The crystal structure of the reduced form of human SSADH

Template:ABSTRACT PUBMED 19300440

Disease

[SSDH_HUMAN] Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.

Function

[SSDH_HUMAN] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).[1]

About this Structure

2w8o is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Kim YG, Lee S, Kwon OS, Park SY, Lee SJ, Park BJ, Kim KJ. Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. Epub 2009 Mar 19. PMID:19300440 doi:10.1038/emboj.2009.40
  1. ↑ Kim YG, Lee S, Kwon OS, Park SY, Lee SJ, Park BJ, Kim KJ. Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. Epub 2009 Mar 19. PMID:19300440 doi:10.1038/emboj.2009.40

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