3alp
From Proteopedia
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{{STRUCTURE_3alp| PDB=3alp | SCENE= }} | {{STRUCTURE_3alp| PDB=3alp | SCENE= }} | ||
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===Cell adhesion protein=== | ===Cell adhesion protein=== | ||
| + | {{ABSTRACT_PUBMED_21325282}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3alp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALP OCA]. | [[3alp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALP OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021325282</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Nakagawa, A.]] | [[Category: Nakagawa, A.]] | ||
Revision as of 19:28, 7 August 2013
Contents |
Cell adhesion protein
Template:ABSTRACT PUBMED 21325282
Disease
[PVRL1_HUMAN] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Function
[PVRL1_HUMAN] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.[1]
About this Structure
3alp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Narita H, Yamamoto Y, Suzuki M, Miyazaki N, Yoshida A, Kawai K, Iwasaki K, Nakagawa A, Takai Y, Sakisaka T. Crystal Structure of the cis-Dimer of Nectin-1: implications for the architecture of cell-cell junctions. J Biol Chem. 2011 Apr 8;286(14):12659-69. Epub 2011 Feb 15. PMID:21325282 doi:10.1074/jbc.M110.197368
